Exercise rehabilitation for patients with critical illness : a randomized controlled trial with 12 months of follow-up.

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Title: Exercise rehabilitation for patients with critical illness : a randomized controlled trial with 12 months of follow-up.
Creator: Denehy, Linda.
Creator: Skinner, Elizabeth.
Creator: Edbrooke, Lara.
Creator: Haines, Kimberley.
Creator: Warrillow, Stephen.
Creator: Hawthorne, Graeme.
Creator: Gough, Karla.
Creator: Vander Hoorn, Steven.
Creator: Morris, Meg.
Creator: Berney, Sue.
Subject: 110317 Physiotherapy
Date: 2013
Publisher: BioMed Central.
Description: Introduction: The purpose of this trial was to investigate the effectiveness of an exercise rehabilitation program commencing during ICU admission and continuing into the outpatient setting compared with usual care on physical function and health-related quality of life in ICU survivors. Methods: We conducted a single-center, assessor-blinded, randomized controlled trial. One hundred and fifty participants were stratified and randomized to receive usual care or intervention if they were in the ICU for 5 days or more and had no permanent neurological insult. The intervention group received intensive exercises in the ICU and the ward and as outpatients. Participants were assessed at recruitment, ICU admission, hospital discharge and at 3-, 6- and 12-month follow-up. Physical function was evaluated using the Six-Minute Walk Test (6MWT) (primary outcome), the Timed Up and Go Test and the Physical Function in ICU Test. Patient-reported outcomes were measured using the Short Form 36 Health Survey, version 2 (SF-36v2) and Assessment of Quality of Life (AQoL) Instrument. Data were analyzed using mixed models. Results: The a priori enrollment goal was not reached. There were no between-group differences in demographic and hospital data, including acuity and length of acute hospital stay (LOS) (Acute Physiology and Chronic Health Evaluation II score: 21 vs 19; hospital LOS: 20 vs 24 days). No significant differences were found for the primary outcome of 6MWT or any other outcomes at 12 months after ICU discharge. However, exploratory analyses showed the rate of change over time and mean between-group differences in 6MWT from first assessment were greater in the intervention group. Conclusions: Further research examining the trajectory of improvement with rehabilitation is warranted in this population.
Funding: This research was completed with funds from the NHMRC (grant 454717), the Physiotherapy Research Foundation, the Austin Hospital Medical Research Foundation and the Australian and New Zealand Intensive Care Society.

Digital Object ID: http://dx.doi.org/10.1186/cc12835
ISSN: 1364-8535
Format: 11 p (p. [1-12].)
Language: en
Rights: Open Access. This article has been reproduced here under the terms of a Creative Commons Attribution License (CC BY 2.0) http://creativecommons.org/licenses/by/2.0
Rights: This licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work). This work was published in Critical Care, 17(4): R156, 2013.
Type: journal article
Source: Critical Care, 17(4): [1-12]

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