Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial.

Ackland, Tim

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Title: Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial.
Creator: Belski. Regina.
Creator: Mori, Trevor
Creator: Puddey, Ian
Creator: Sipsas, Sofia
Creator: Woodman, Richard
Creator: Ackland, Tim
Creator: Beilin, Lawrie
Creator: Dove, Emma
Creator: Carlyon, Nichole
Creator: Jayasena, Jayasena
Creator: Hodgson, Jonathan
Subject: 111102 Dietetics and Nutrigenomics
Date: 2011.
Publisher: Nature Publishing Group.
Description: Background: Regular consumption of diets with increased protein or fibre intakes may benefit body weight and composition and cardiovascular disease risk factors. Lupin flour is a novel food ingredient high in protein and fibre. Objective: To investigate the effects of a lupin-enriched diet, during and following energy restriction, on body weight and composition and cardiovascular disease risk factors in overweight individuals. Design: Participants (n¼131) were recruited to a 12-month parallel-design trial. They were randomly assigned to consume lupin-enriched foods or matching high-carbohydrate control foods. All participants underwent 3 months of weight loss, 1 month of weight stabilization and 8 months of weight maintenance. Body weight and composition and cardiovascular disease risk factors were assessed at baseline, 4 and 12 months. Results: Lupin, relative to control, did not significantly influence (mean difference (95% CI)) weight loss at 4 months (0.1 kg ( 1.2, 1.4)) and 12 months ( 0.6 kg ( 2.0, 0.8)), maintenance of weight loss from 4 to 12 months ( 0.7 kg ( 1.83, 0.48)) or measures of body fat and fat-free mass. Relative to control, 24-h ambulatory systolic ( 1.3mmHg ( 2.4, 0.3), P¼0.016) and diastolic ( 1.0mmHg ( 1.9, 0.2), P¼0.021) blood pressures were lower at 12 months but not at 4 months; fasting insulin concentrations and homeostasis model assessment (HOMA) scores were significantly lower at 4 months ( 1.2mUl–1 ( 1.3, 1.1), P¼0.004 and 0.6 units ( 1.0, 0.19), P¼0.004) and 12 months ( 1.3 mUl–1 ( 1.4, 1.1), Po0.001 and 0.7 units ( 1.1, 0.24), P¼0.002). Conclusions: A diet higher in protein and fibre derived from lupin-enriched foods does not enhance weight loss or improve the maintenance of weight loss. However, such a diet may provide cardiovascular health benefits in terms of insulin sensitivity and blood pressure.

Digital Object ID: http://dx.doi.org/10.1038/ijo.2010.213
ISSN: 1476-5497
Format: 10 p. (p. 810-819).
Language: en
Type: journal article
Source: International journal of obesity, 35(6): 810-819

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